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    Includes everything a competent pediatrician is expected to know

    Neonatology

    Mortality / Morbidity in Newborns
    * Common Terms
    * Factors Associated With Neonatal Mortality

    The Placenta
    * Placental Development
    * The Umbilical Cord
    * Chorioamnionitis
    * Abnormalities of the Placenta
    * Issues of Twins and Their Placentas

    Prenatal Care
    * Well-Mother Health
    * Prophylaxis for Group B Streptococcus (GBS)
    * Preterm Complications
    * Assessing Fetal Health

    Cesarean Section (C-Section)

    Operative Vaginal Delivery

    Fetal-to-Newborn Transitions
    * Respiratory Transitions
    * Circulatory Transition after Birth-
    * Glucose Transitions
    * Water Balance

    The Delivery Room
    * Apgar
    * Delivery Room Resuscitation
    * Delivery Room Temperature

    The Newborn Examination
    * Note
    * Gestational Age / Size
    * Physical Examination
    * Crying in the Newborn
    * Temperature
    * Skin
    * Head
    * Eyes
    * Ears
    * Nose
    * Mouth
    * Neck
    * Chest
    * Lungs
    * Heart
    * Abdomen
    * Genitalia
    * Anus
    * Spinal Column
    * Extremities
    * Neurologic Exam

    Neonatal Prophylaxis
    * Eye Prophylaxis
    * Vitamin K
    * Hepatitis B
    * Cord Care
    * Circumcision

    Neonatal Screening
    * Glucose
    * Hematocrit
    * Blood Type
    * Inborn Errors of Metabolism

    Hemoglobinopathies
    * Hearing
    * Cyanotic Congenital Heart Disease (CCHD)
    * Toxic Substances / Illicit Drugs

    Multiple Births
    * Epidemiology
    * Prenatal Assessment
    * Delivery and Perinatal Problems

    Small for Gestational Age (SGA)

    Teratogens
    * Teratogenic Drugs
    * Maternal Exposures and Substance Use
    * Maternal Diseases
    * Maternal Infections

    Infants of Mothers with Diabetes

    Congenital Infections
    * Overview
    * Congenital Syphilis
    * Sepsis in the Newborn

    Neonatal Respiratory Distress
    * Transient Tachypnea of the Newborn (TTN)
    * Respiratory Distress Syndrome (RDS)
    * Group B Streptococcus (GBS)
    * Persistent Pulmonary Hypertension of the Newborn (PPHN)
    * Apnea-Meconium Aspiration Syndrome (MAS)
    * Congenital Diaphragmatic Hernia (CDH)
    * Pneumothorax and Pneumomediastinum
    * Bronchopulmonary Dysplasia (BPD)
    * Pulmonary Hemorrhage in the Newborn

    Patent Ductus Arteriosus (PDA)

    Gastrointestinal (GI) Disorders in Newborns
    * Note
    * Meconium Plugs
    * Meconium Ileus-Necrotizing Enterocolitis (NEC)
    * Malrotation
    * Intestinal Atresia
    * Newborn Hyperbilirubinemia

    Blood Disorders in the Newborn
    * Polycythemia
    * Hemolytic Disease of the Fetus and Newborn (HDFN)

    Hospital Discharge of the Healthy Newborn

    Growth & Development

    Overview of Growth
    * Normal Growth Patterns
    * Midparental Height (MPH)
    * Growth Charts
    * Growth Pattern Variations

    Constitutional Growth Delay (CGD)

    Failure to Thrive (FTT)

    Obesity / Overweight Screening
    * Obesity
    * Metabolic Syndrome

    Head Malformations

    Developmental Milestones
    * Overview
    * Developmental Delay
    * Intellectual Disability
    * Speech / Language Delay
    * Autism Screening
    * Extra Questions

    School Accommodations and Interventions
    * Overview
    * Education Plans and Legislation
    * Accommodations

    Toilet Training
    * Overview
    * Signs of Readiness
    * A Child-Oriented Approach
    * Toilet Training Refusal

    Discipline

    Nutrition

    Normal Nutrition

    Nutrition, Calorie, and Fluid Requirements
    * Overview
    * Breastfeeding
    * Formula Feeding
    * Vitamin and Mineral

    Supplementation
    * Advancing the Diet
    * Enteral Nutrition
    * Parenteral Nutrition

    Refeeding Syndrome

    Nutritional Disorders
    * Marasmus
    * Kwashiorkor
    * Etiology-Based Malnutrition
    * Fat-Soluble Vitamin Deficiencies
    * Water-Soluble Vitamin Deficiencies
    * Pica

    Vegetarian and Vegan Diets

    Preventive Pediatrics

    Screening in Children
    * Note
    * Newborn Screening
    * Vision and Hearing Screening
    * Body Mass Index (BMI) Screening
    * Blood Pressure (BP) Screening
    * Lead Screening
    * Iron Deficiency Screening
    * Autism Spectrum Disorder Screening
    * Urine Screening
    * Cholesterol and Lipid Screening
    * Tuberculosis (TB) Screening
    * Sexually Transmitted Infection (STI) Screening

    Dental Care

    Sleep Issues

    Crying / Colic

    Safety and Injury Prevention
    * Overview
    * Causes of Mortality
    * Child Safety Restraints
    * Other Safety Items

    "The Shots"
    * Overview
    * Vaccine Administration and Storage
    * Live Vaccines
    * Adverse Events, Contraindications, and Precautions
    * Postexposure Prophylaxis
    * Pregnancy
    * Vaccine Hesitancy
    * The Immunization Schedules
    * DTaP / DT / Tdap / Td Vaccine
    * Measles, Mumps, Rubella (MMR) Vaccine
    * Varicella Vaccine
    * Inactivated Poliovirus (IPV) and Oral Poliovirus (OPV)
    * Haemophilus influenzae Type b (Hib) Vaccine
    * Hepatitis A Vaccine
    * Hepatitis B Vaccine
    * Pneumococcal Vaccines
    * Meningococcal Vaccine
    * Rotavirus Vaccine
    * Influenza Vaccine
    * Human Papillomavirus (HPV) Vaccine
    * COVID-19 Vaccines

    Immigrant and Internationally Adopted Children

    Preventive Measures for International Travel

    Appendix — Blood Pressure Charts

    Adolescent Medicine & Sexual Health

    Special Issues of Adolescents

    The Developing Adolescent
    * General Considerations
    * Adolescent Behavior
    * Emancipation and Health Care
    * The Adolescent Health Visit
    * Eating Disorders
    * Self-Injurious Behavior in Adolescents
    * Intimate Partner Violence
    * Sexual Development
    * Contraception
    * Sexual Behavior in Children and Adolescents
    * Sexual Exploration

    Sexually Transmitted Infections (STIs)
    * Prevalence of STIs
    * Prevention
    * Reporting and Confidentiality
    * Pregnant Adolescents
    * Children with STIs
    * Human Immunodeficiency Virus (HIV)
    * STIs Characterized by Genital Ulcers
    * STIs with Urethritis and Cervicitis
    * Disseminated Gonococcal Infection (DGI)
    * Infections with Vaginal Discharge
    * Pelvic Inflammatory Disease (PID)
    * Epididymitis
    * Human Papillomavirus (HPV) Infection
    * Cervical Cancer Screening
    * Proctitis, Proctocolitis, and Enteritis
    * Ectoparasitic Infections
    * Vaccine-Preventable Sexually Transmitted Infections (STIs)

    Behavioral Medicine & Substance Use Disorders

    Common Behavioral Issues
    * Colic
    * Sleep Problems
    * Temper Tantrums and Breath Holding
    * Stress
    * Separation Anxiety
    * School Refusal
    * School Overachievement
    * Repetitive Habits and Behaviors

    Psychosocial Issues
    * Birth of a Sibling
    * Adoption
    * Foster Care
    * Divorce
    * Family Death / Terminal Illness
    * Family Chronic Illness
    * Impact of Mass Media
    * Impact of Racism on Child and Adolescent Health
    * Undocumented Immigrants

    Disruptive Behaviors
    * Oppositional Defiant Disorder (ODD)
    * Conduct Disorder

    Autism Spectrum Disorder (ASD)
    * Overview
    * Treatment

    Tic Disorders
    * Overview
    * Tourette Syndrome
    * Provisional Tic Disorder

    Rett Syndrome

    Mental Health Disorders
    * Features of Psychotic and Mood Disorders
    * Schizophrenia
    * Depression
    * Bipolar Disorder
    * Nonsuicidal Self-Injury (NSSI)
    * Anxiety Disorders
    * Posttraumatic Stress Disorder (PTSD)
    * Obsessive-Compulsive Disorder (OCD)
    * Psychosomatic Disorders
    * Factitious Disorder Imposed on Another

    Attention Deficit Hyperactivity Disorder (ADHD)
    * Overview
    * Comorbidities
    * Etiology
    * Clinical Findings
    * Laboratory
    * Treatment
    * Prognosis

    Substance Use Disorders (SUDs)
    * Overview
    * Alcohol
    * Nicotine
    * Marijuana
    * Cocaine
    * Psychoactive Drugs
    * Synthetic Cathinones (Bath Salts)
    * Benzodiazepines (BDZs)
    * Barbiturates
    * Inhalants
    * Hallucinogens
    * Androgenic Steroids
    * Summary of Key Clinical Findings

    Suicide

    Emergency Medicine & Maltreatment Syndromes

    Poisonings
    * Overview
    * Initial Management
    * Acetaminophen Ingestion
    * Salicylate Ingestion
    * Ibuprofen Ingestion
    * Opiate / Opioid Poisoning
    * Antihypertensive Ingestion
    * Iron Ingestion
    * Anticholinergic Ingestion
    * Tricyclic Antidepressant (TCA) Ingestion
    * Serotonin Syndrome and Neuroleptic Malignant Syndrome
    * Oral Hypoglycemic Agents
    * Methemoglobinemia

    Environmental Ingestions and Exposures
    * Lead
    * Carbon Monoxide (CO)
    * Cyanide
    * Caustic Substance Ingestion
    * Hydrocarbon Poisoning
    * Ethanol Ingestion
    * Methanol Ingestion
    * Ethylene Glycol Ingestion
    * Organophosphate Poisoning
    * Plant Exposures

    Foreign Body Ingestion or Aspiration

    Bites
    * Dog / Cat Bites
    * Human Bites
    * Snake Bites
    * Spider Bites

    Laceration and Punctures

    Burns
    * Overview
    * Minor Burn Care
    * Major Burn Care

    Submersion Injury

    Head Injury
    * Overview
    * Neuroimaging
    * Mild Traumatic Brain Injury (mTBI)

    Electrical Burns

    Ocular Chemical Burns

    Chest Wall Trauma

    Blunt Abdominal Trauma

    Fractures
    * Overview
    * Greenstick Fracture
    * Torus (Buckle) Fracture
    * Spiral Fracture
    * Clavicle Fracture
    * Distal Humerus (Elbow) Fracture
    * Fracture Complications

    Subluxation of the Radial Head

    Shoulder Injuries

    Sprains

    Brief Resolved Unexplained Event (BRUE)

    Shock

    Pediatric Advanced Life Support (PALS)
    * Overview
    * Circulation
    * Postarrest Care

    Neonatal Resuscitation

    Child Maltreatment Syndromes
    * Overview
    * Neglect
    * Physical Abuse
    * Sexual Abuse
    * Psychological Maltreatment

    Management and Prevention of Maltreatment

    Pharmacology and Pain Management

    Pharmacology
    * Overview
    * Pharmacokinetics
    * Pharmacodynamics
    * Bioequivalence

    Sedation
    * Overview
    * Patient Characteristics
    * Degrees of Sedation
    * Risk Factors for Sedation
    * Related Adverse Events (SRAEs)
    * SRAEs
    * Reduction of SRAEs
    * Sedation Agent Profiles

    Analgesia
    * Overview
    * Local and Topical Agent Profiles
    * Systemic Treatment Profiles

    Musculoskeletal & Sports Medicine

    Congenital Disorders
    * Torticollis
    * Clubfoot
    * Intoeing
    * Polydactyly
    * Sprengel Deformity
    * Klippel-Feil Syndrome
    * Osteogenesis Imperfecta
    * Achondroplasia
    * Scoliosis
    * Kyphosis
    * Pectus Excavatum
    * Pectus Carinatum

    Back Pain

    Disorders of the Lower Extremity
    * Causes of Leg Length Discrepancy
    * Developmental Dysplasia of the Hip (DDH)
    * Blount Disease

    Limb Pain
    * Overview
    * Evaluation of the Limping Child
    * Growing Pains
    * Bone Neoplasms
    * Osteoid Osteoma
    * Osgood-Schlatter Disease
    * Transient Synovitis
    * Legg-Calvé-Perthes Disease
    * Slipped Capital Femoral Epiphysis (SCFE)

    Heel and Foot Pain

    Bone Injuries and Benign Lesions
    * Compartment Syndrome
    * Growth Plate Injuries
    * Bone Lesions
    * Osteochondroma
    * Traumatic Myositis Ossificans
    * Fractures

    Preparticipation Physical Evaluation (PPE)

    Sports Injury Prevention and Treatment
    * Overview
    * Heat Illness
    * Mild Traumatic Brain Injury (mTBI; Concussion)
    * Overuse Injuries
    * Sprains and Strains
    * Shoulder Dislocation / Subluxation
    * Knee Injuries
    * Ankle Sprain

    Nutritional Requirements

    Relative Energy Deficiency in Sport (RED-S)

    Performance-Enhancing Substances (PESs)

    Gastroenterology

    Vomiting
    * Overview
    * Infant Regurgitation
    * Cyclic Vomiting Syndrome (CVS)
    * Rumination Syndrome
    * Gastroparesis

    Abdominal Pain
    * Overview
    * History / Workup
    * Functional Abdominal Pain

    Acute Diarrhea
    * History / Workup
    * Oral Rehydration Therapy
    * Feeding During Acute Diarrhea
    * Use of Antidiarrheal Agents

    Chronic Diarrhea

    Constipation
    * Overview
    * Infant Dyschezia
    * Functional Constipation

    Esophagus Disorders
    * Tracheoesophageal Fistulas (TEFs) and Esophageal Atresias (EAs)
    * Achalasia
    * Gastroesophageal Reflux (GER)
    * Eosinophilic Esophagitis (EoE)
    * Infections of the Esophagus
    * Caustic Ingestions
    * Pill-Induced Esophagitis
    * Ingestion of Foreign Bodies
    * Esophageal Perforation
    * Esophageal Varices

    Stomach Disorders
    * Pyloric Stenosis
    * Erosive and Hemorrhagic Gastropathy
    * Nonerosive Gastropathy
    * Peptic Ulcer Disease (PUD)

    Intestinal Disorders
    * Malrotation of the Intestine
    * Intussusception
    * Meckel Diverticulum
    * Congenital Intestinal Atresias
    * Gastrointestinal (GI) Duplications
    * Meconium Ileus
    * Carbohydrate Malabsorption
    * Congenital Transport Defects
    * Short Bowel Syndrome
    * Superior Mesenteric Artery (SMA) Syndrome
    * Celiac Disease (Gluten-Sensitive Enteropathy)
    * Tropical Sprue
    * Whipple Disease
    * Appendicitis
    * Neutropenic Enterocolitis

    Inflammatory Bowel Disease (IBD)
    * Overview
    * Ulcerative Colitis (UC)
    * Crohn Disease
    * Treatment

    Colonic Polyps and Tumors
    * Overview
    * Juvenile Polyps and Juvenile Polyposis
    * Peutz-Jeghers Syndrome
    * Syndromes Linked to PTEN Gene Mutations
    * Proteus Syndrome
    * Familial Adenomatous Polyposis

    Congenital Ventral Abdominal Wall Defects
    * Occurrence
    * Omphalocele
    * Gastroschisis

    Anorectal Disorders
    * Occurrence
    * Male Anorectal Disorders
    * Female Anorectal Disorders
    * Anorectal Disorders Presenting Similarly in Both Sexes

    Hirschsprung Disease
    * Occurrence-
    * Pathogenesis
    * Presentation
    * Diagnosis
    * Treatment

    Disorders of the Exocrine Pancreas
    * Note
    * Cystic Fibrosis (CF)
    * Schwachman-Diamond Syndrome
    * Acute Pancreatitis
    * Chronic Pancreatitis

    Diseases of the Liver and Biliary Tree
    * Jaundice Beyond the Neonatal Period
    * Congenital Disorders of Liver Structure
    * Congenital Anomalies of the Biliary Tree
    * Liver Trauma
    * Viral Hepatitis
    * Metabolic Liver Diseases
    * Drug-Induced Liver Injury (DILI)
    * Autoimmune Hepatobiliary Disease
    * Biliary Atresia
    * Cholelithiasis
    * Acute Cholecystitis
    * Hydrops of the Gallbladder
    * Tumors of the Liver and Biliary Tree

    Pulmonary Medicine

    Normal Respiration

    Diagnostic Testing
    * Lung Volumes and Pulmonary Function Tests (PFTs)
    * Pulse Oximetry
    * Blood Gas Analysis

    Ventilatory Support

    Neonatal Stridor
    * Note
    * Laryngomalacia
    * Subglottic Stenosis
    * Vocal Cord Paralysis
    * Laryngeal Atresia / Webs

    Congenital Disorders of the Lower Respiratory Tract
    * Tracheal Disorders
    * Pulmonary Hypoplasia
    * Congenital Pulmonary Venolobar Syndrome (Scimitar Syndrome)
    * Pulmonary Arteriovenous Malformations (PAVMs)
    * Pulmonary Sequestrations
    * Bronchogenic Cysts
    * Congenital Pulmonary Airway Malformation (CPAM)
    * Diaphragm Malformations

    Neuromuscular Respiratory Failure

    Stridor Beyond the Neonatal Period
    * Infection
    * Paradoxical Vocal Cord Dysfunction (VCD)

    Infections of the Upper Respiratory Tract
    * Note
    * Croup (Laryngotracheobronchitis)
    * Epiglottitis
    * Bacterial Tracheitis

    Infections of the Lower Respiratory Tract
    * Bronchiolitis
    * Pneumonia — General Considerations
    * Viral Pneumonia
    * Acute Bacterial Pneumonia
    * Atypical Pneumonias
    * Fungal Pneumonias
    * Recurrent Pneumonia
    * Tuberculosis (TB)

    Asthma
    * Overview
    * Classification
    * Comorbidities and Triggers
    * Treatment
    * Acute Exacerbation

    Differential Diagnosis of Wheezing

    Nonasthma Causes of Chronic Cough
    * Overview
    * Common Causes
    * Cryptogenic Organizing Pneumonia (COP)
    * Bronchiolitis Obliterans (BO)
    * Bronchiectasis

    Sudden Infant Death Syndrome (SIDS)

    Cystic Fibrosis (CF)
    * Overview
    * Manifestations
    * Diagnosis
    * Treatment
    * Complications

    Primary Ciliary Dyskinesia (PCD)

    α1-Antitrypsin Deficiency (AATD)
    * Overview
    * Diagnosis
    * Treatment

    Hemoptysis
    * Overview
    * Idiopathic Pulmonary Hemosiderosis (IPH)

    Interstitial Lung Diseases (ILDs)
    * Overview
    * Lymphocytic Interstitial Pneumonia (LIP)
    * Sarcoidosis
    * Pulmonary Alveolar Proteinosis

    The Lungs in Autoimmune Diseases
    * Overview
    * Systemic Lupus Erythematosus (SLE)
    * Scleroderma
    * Sjögren Syndrome
    * Granulomatosis with Polyangiitis (GPA)
    * Anti–Glomerular Basement Membrane (Anti-GBM)
    * Disease with Pulmonary Hemorrhage

    Appendix — Asthma Treatment Regimens

    Neurology

    Congenital Anomalies of the Central Nervous System (CNS)
    * Neural Tube Defects (NTDs)
    * Syringomyelia
    * Hydrocephalus
    * Chiari Malformation
    * Klippel-Feil Syndrome
    * Migrational Anomalies
    * Polymicrogyria
    * Lissencephaly
    * Schizencephaly
    * Holoprosencephaly
    * Agenesis of the Corpus Callosum

    Cerebral Palsy (CP)
    * Definitions
    * Etiology
    * Types of CP
    * Seizures and Intellectual Disability
    * Diagnosis
    * Treatment

    Chorea

    Narcolepsy

    Cerebrovascular Diseases
    * Overview
    * Clinical Features
    * Differential Diagnosis
    * Ischemic Stroke
    * Hemorrhagic Stroke
    * Cerebral Vein Thrombosis

    Injury / Trauma to the Central and Peripheral Nervous Systems
    * Occurrence
    * Scalp Injuries
    * Skull Fractures
    * Parenchymal Injuries
    * Spinal Cord Injury
    * Common Peripheral Nerve Injuries

    Cranial Nerve (CN) Abnormalities
    * CN Review
    * Facial Nerve Palsy
    * Marcus Gunn Phenomenon

    Seizure Disorders
    * Occurrence
    * Generalized Seizures
    * Focal Seizures
    * Infantile Spasms
    * Lennox-Gastaut Syndrome
    * Posttraumatic Seizures
    * Neurocutaneous Syndromes
    * Other Seizure Types
    * Management
    * Drug Therapy and Side Effects
    * Common Epilepsy Questions
    * Status Epilepticus
    * Neonatal Seizures
    * Febrile Seizures

    Headache
    * Etiologies
    * Primary Headache Disorders
    * Organic Headaches
    * CT / MRI Evaluation of Headaches

    Neuromuscular Diseases
    * Overview
    * Spinal Muscular Atrophy (SMA)
    * Duchenne Muscular Dystrophy (DMD)
    * Becker Muscular Dystrophy
    * Myasthenia Gravis
    * Guillain-Barré Syndrome
    * Charcot-Marie-Tooth Disease
    * Botulism
    * Transverse Myelitis
    * Multiple Sclerosis (MS)

    Ataxia
    * Overview
    * Acute Cerebellar Ataxia of Childhood
    * Friedreich Ataxia
    * Ataxia Telangiectasia

    Other Diseases of the Central Nervous System (CNS)

    Cardiology

    Physical Examination
    * Overview
    * Skin
    * Arterial Pulses
    * Venous Pulses
    * Inspection and Palpation
    * Auscultation of the Heart
    * Common Pediatric Murmurs

    The 15-Lead Electrocardiogram (ECG)
    * The Basics
    * Axis Deviations
    * Rates and Intervals
    * Waveforms and Segments
    * Ventricular Hypertrophy

    Chest Pain
    * Overview
    * Acute-Onset, Severe Chest Pain
    * Chronic and Recurrent Chest Pain

    Syncope

    Cardiovascular Preparticipation Physical Evaluation

    Preventive Cardiology

    Arrhythmias
    * Mechanisms of Arrhythmias
    * Clinical Manifestations of Cardiac Arrhythmias / Dysrhythmias
    * Sinus Bradycardia, Sinus Arrhythmia, and Extrasystoles
    * Supraventricular Arrhythmias
    * Ventricular Arrhythmias
    * Cardiac Pacing

    Sick Sinus Syndrome

    Antiarrhythmic Drugs (AADs)

    Conduction Disorders
    * Long QT Syndrome
    * Atrioventricular (AV) Blocks
    * Heart Block Treatment
    * Bundle-Branch Block (BBB)

    Occurrence / Causes of Congenital Heart Disease

    Left-to-Right Shunts
    * Overview
    * Ventricular Septal Defect (VSD)
    * Patent Ductus Arteriosus (PDA)
    * Patent Foramen Ovale (PFO)
    * Atrial Septal Defect (ASD)
    * Complete AV Canal Defect
    * Pulmonary Hypertension
    * Eisenmenger Syndrome

    Right-to-Left Shunts
    * Overview
    * Tetralogy of Fallot (TOF)
    * Transposition of the Great Arteries
    * Tricuspid Atresia
    * Pulmonary Atresia With Intact Ventricular Septum

    Other Cyanotic Lesions — “Mixing” Lesions
    * Overview
    * Truncus Arteriosus
    * Total Anomalous Pulmonary Venous Return (TAPVR)
    * Hypoplastic Left Heart Syndrome (HLHS)

    Malpositions

    Obstructive Lesions
    * Coarctation of the Aorta (CoA)
    * Aortic Stenosis (AS)
    * Supravalvular AS
    * Pulmonic Stenosis (PS; Pulmonary Stenosis)
    * Peripheral Branch Stenosis
    * Mitral Stenosis
    * Tricuspid Stenosis
    * Hypertrophic Cardiomyopathy (HCM)

    Regurgitant Lesions
    * Aortic Regurgitation
    * Mitral Regurgitation (MR)
    * Mitral Valve Prolapse (MVP)
    * Pulmonic Regurgitation
    * Tricuspid Regurgitation
    * Ebstein Anomaly (EA)

    Coronary Artery Anomalies
    * Anomalous Origin of the Left Coronary Artery
    * Anomalous Origin of the Left or Right Coronary Artery From the Aorta

    Vascular Rings and Slings

    Rheumatic Fever (RF)
    * Causes / Signs and Symptoms
    * Manifestations
    * Proof of Group A Streptococcus (GAS)
    * Treatment
    * Prognosis

    Endocarditis
    * Infective Endocarditis
    * Antibiotic Prophylaxis for Infective Endocarditis

    Kawasaki Disease (KD)

    Myocarditis

    Cardiomyopathy
    * Overview
    * Dilated Cardiomyopathy
    * Hypertrophic Cardiomyopathy
    * Restrictive Cardiomyopathy

    Pericardial Diseases
    * Pericarditis
    * Constrictive Pericarditis
    * Postpericardiotomy Syndrome

    Heart Failure (HF)
    * Overview
    * Symptoms
    * Diagnosis
    * Treatment

    Nephrology & Urology

    Normal Renal Physiology and Diuretics
    * Overview
    * Glomerulus
    * Proximal Convoluted Tubule
    * Loop of Henle
    * Distal Convoluted Tubule
    * Collecting Duct
    * Diuretics — Notes To Know!

    Renal Testing
    * Urinalysis (U/A)
    * Kidney Function
    * Imaging
    * Kidney Biopsy
    * Serum pH

    Composition of Body Fluids
    * Total Body Water (TBW)
    * Fluid Compartments
    * Osmolality and Volume Status
    * Normal Fluid Requirements

    Electrolyte Abnormalities
    * Sodium
    * Potassium
    * Calcium

    Acid-Base Disorders
    * Respiratory vs. Metabolic Disorders
    * Mechanisms
    * Anion Gaps
    * Osmol Gap (OG)
    * Analysis of Acid-Base Problems
    * Metabolic Alkalosis
    * Metabolic Acidosis

    Hematuria

    Glomerulonephritis (GN)
    * Overview
    * Acute Postinfectious Glomerulonephritis (PIGN)
    * Membranoproliferative Glomerulonephritis (MPGN)
    * Lupus Nephritis
    * Rapidly Progressive Glomerulonephritis (RPGN)
    * Immunoglobulin A (IgA) Nephropathy
    * IgA Vasculitis Nephritis (IgAV Nephritis)
    * Anti–Glomerular Basement Membrane Disease (Anti-GBM Disease)
    * Antineutrophil Cytoplasmic Antibody (ANCA)
    * Positive Focal Necrotizing Glomerulonephritis

    Proteinuria

    Nephrotic Syndrome
    * Overview
    * Complications
    * Minimal Change Disease (MCD)
    * Focal Segmental Glomerulosclerosis (FSGS)
    * Membranous Nephropathy

    Hemolytic Uremic Syndrome (HUS)
    * Occurrence
    * Clinical Manifestations
    * Laboratory Findings
    * Treatment

    Renal Tubular Acidosis (RTA)
    * Overview
    * Distal (Type 1) RTA
    * Proximal (Type 2) RTA
    * Type 4 RTA (Hypoaldosteronism)-Types of RTA — Review
    * RTA Scenarios

    Hereditary Glomerulopathies
    * Alport Syndrome
    * Thin Basement Membrane Nephropathy
    * Denys-Drash Syndrome
    * Fabry Disease
    * Nail-Patella Syndrome

    Cystic Diseases of the Kidneys
    * Polycystic Kidney Disease
    * Nephronophthisis (NPH)
    * Tuberous Sclerosis Complex (TSC)
    * Medullary Sponge Kidney
    * Bardet-Biedl Syndrome
    * Congenital Cystic Anomalies of the Kidney

    Tubular and Interstitial Diseases
    * Overview
    * Renal Tubular Acidosis
    * Acute Interstitial Nephritis (AIN)
    * Chronic Interstitial Nephritis (CIN)

    Other Drug-Induced Nephropathies

    Hypertension (HTN)

    Acute Kidney Injury (AKI)
    * Overview
    * Prerenal AKI
    * Intrinsic (Intrarenal) AKI
    * Obstructive (Postrenal) AKI
    * Tips to Etiology of AKI
    * Treatment

    Chronic Kidney Disease (CKD)
    * Overview
    * Clinical Manifestations
    * Diagnosis
    * Management
    * Dialysis
    * Kidney Transplant

    Pregnancy and Kidney Disease

    Kidney-Associated Anemias

    Kidney Stones
    * Overview
    * Calcium
    * Struvite
    * Cystine
    * Uric Acid
    * Treatment for Ureteral Obstruction

    Urinary Tract Infections (UTIs)

    Normal Development and Urologic Abnormalities
    * Normal Renal Development
    * Prenatally Diagnosed Hydronephrosis
    * Kidney and Ureter Anomalies
    * Vesicoureteral Reflux (VUR)
    * Bladder and Urethral Abnormalities
    * Disorders of Voiding
    * Inguinal Swelling and Masses
    * Male Genital System Abnormalities
    * Female Genital System Abnormalities

    Endocrinology

    Hypothalamus and Pituitary Disorders
    * Overview
    * Hormones of the Hypothalamus and Pituitary
    * Hypopituitarism and Growth Hormone (GH) Deficiency
    * Diabetes Insipidus (DI)
    * Endocrine Causes of Hyponatremia
    * Primary Hyperpituitarism

    Puberty
    * The Pituitary and the Hypothalamic Pituitary-Gonadal (HPG) Axis
    * Clinical Physiology
    * Precocious Puberty

    Thyroid Disorders
    * Normal Thyroid Physiology
    * Thyroid Function Tests (TFTs)
    * Thyroxine-Binding Globulin (TBG)
    * Scans / Ultrasound
    * Thyroglossal Duct Cyst
    * Hypothyroidism
    * Hyperthyroidism
    * Thyroid Cancer

    Parathyroid Disorders
    * Overview
    * Hypoparathyroidism
    * Pseudohypoparathyroidism
    * Rickets
    * Hyperparathyroidism
    * Familial Hypocalciuric Hypercalcemia (FHH)
    * Granulomatous Disease
    * Hypercalcemia of Malignancy

    Adrenal Disorders
    * The Hypothalamic-Pituitary-Adrenal (HPA) Axis
    * Adrenal Insufficiency

    Congenital Adrenal Hyperplasia (CAH)
    * Overview
    * Causes
    * Clinical Manifestations
    * Laboratory Findings
    * Diagnosis
    * Prenatal Diagnosis and Treatment
    * Postdelivery Treatment

    Cushing Syndrome
    * Overview
    * Adrenocorticotropic Hormone (ACTH)
    * Independent Cushing Syndrome
    * ACTH
    * Dependent Cushing Syndrome
    * Clinical Manifestations
    * Laboratory Findings
    * Differential Diagnosis
    * Treatment

    Hyperaldosteronism
    * Overview
    * Primary Hyperaldosteronism
    * Secondary Hyperaldosteronism

    Pseudohyperaldosteronism

    Pheochromocytoma (Pheo)
    * Overview
    * Clinical Manifestations
    * Diagnosis
    * Treatment

    Male Hypogonadism
    * Primary Hypogonadism
    * Secondary (Hypogonadotropic) Hypogonadism

    Female Hypogonadism
    * Note
    * Primary Hypogonadism
    * Secondary Hypogonadism
    * Polycystic Ovary Syndrome (PCOS)

    Gynecomastia

    Differences of Sexual Development (DSDs)
    * Overview
    * 46,XX DSDs
    * 46,XY DSDs
    * Ovotesticular DSD
    * Congenital Genital Malformations

    Polyuria in a Child

    Diabetes Mellitus (DM)
    * Overview
    * Type 1 DM
    * Type 2 DM
    * Metabolic Syndrome
    * Monogenic Diabetes — Maturity-Onset Diabetes of Youth (MODY)
    * Insulin Resistance Syndromes

    Hypoglycemia

    Allergy & Immunology

    Hypersensitivity Reactions
    * Overview
    * Type 1 — Immediate Hypersensitivity Reaction
    * Type 2 — Cytotoxic Hypersensitivity
    * Type 3 — Immune Complex (IC) Hypersensitivity
    * Type 4 — Cell-Mediated Hypersensitivity

    Allergic Disorders
    * Overview
    * Anaphylaxis
    * Urticaria
    * Angioedema
    * Asthma
    * Allergic Rhinitis and Conjunctivitis
    * Immunoglobulin E (IgE)
    * Mediated Food Allergy
    * Non-IgE-Mediated Food Allergy
    * Insect Allergy
    * Latex Allergy
    * Radiocontrast Media (RCM) Reactions
    * Allergy Testing and Other Laboratory Tests

    Adverse Drug Reactions
    * Overview
    * Immunoglobulin E (IgE)
    * Mediated Penicillin Allergy
    * Vancomycin Reactions
    * Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome
    * Fixed Drug Eruption
    * Stevens-Johnson Syndrome (SJS) / Toxic Epidermal Necrolysis (TEN)
    * Serum Sickness (SS) and Serum Sickness–Like Reactions (SSLRs)

    Mastocytosis

    Eczema
    * Atopic Dermatitis (AD)
    * Contact Dermatitis

    Review of the Immune System
    * Note
    * The Innate Immune System
    * The Adaptive Immune System
    * Innate vs. Adaptive Immunity
    * Innate and Adaptive Overlap
    * Innate-Like Cells
    * Cells of the Immune System
    * Cell Recognition and Communication

    Human Leukocyte Antigens (HLAs)

    Lymphoid Cells
    * Lymphocytes
    * Natural Killer (NK) Cells

    Myeloid Cells

    Antibodies

    Complement
    * Overview
    * The 3 Complement Pathways
    * Common Terminal Pathway — Membrane Attack Complex (MAC)

    Immunodeficiencies
    * Overview
    * Primary B-Cell Immunodeficiencies
    * Primary T-Cell Immunodeficiencies
    * Combined B- and T-Cell Immunodeficiencies
    * Phagocyte Disorders
    * Complement Disorders
    * Screening Tests for Immunodeficiencies
    * Vaccine Use in Immunocompromised Children

    Infectious Disease

    Congenital and Perinatal Infections
    * Overview
    * Toxoplasmosis
    * Syphilis
    * Rubella
    * Cytomegalovirus (CMV)
    * Herpes Simplex Virus (HSV)
    * Human Parvovirus B19
    * Varicella
    * Enterovirus
    * Group B Streptococcus (GBS)
    * Listeria
    * Congenital Zika Syndrome

    Infectious Disease Syndromes
    * Fever Without a Source (FWS) in Infants and Children
    * Fever of Unknown Origin (FUO)
    * Lymphadenopathy
    * Sepsis
    * Central Nervous System (CNS) Infections
    * Gastrointestinal (GI) Infections
    * Genitourinary and Sexually Transmitted Infections
    * Soft Tissue Infections
    * Bone and Joint Infections
    * Infective Endocarditis (IE)
    * Health Care–Associated (Nosocomial) Infections

    Vaccines

    Prevention of Infectious Diseases
    * Note
    * Child Care Centers
    * Hospital and Office Infection Control
    * Infections Transmitted via Breast Milk

    Evaluation of International Adoptees
    * Overview
    * Immunizations

    Bacteria
    * Gram-Positive Cocci
    * Gram-Positive Rods
    * Gram-Negative Cocci
    * Gram-Negative Coccobacilli
    * Gram-Negative Rods
    * Atypical Organisms
    * Gram-Variable Bacteria
    * Anaerobes
    * Acid-Fast Bacteria

    Spirochetes
    * Syphilis
    * Leptospirosis
    * Lyme Disease

    Fungi
    * Overview
    * Candida
    * Cryptococcus
    * Coccidioides, Histoplasma, and Blastomyces
    * Aspergillosis
    * Dermatophytes
    * Malassezia
    * Sporotrichosis
    * Mucormycosis
    * Pneumocystis jiroveci

    Parasites
    * Classification
    * Protozoa
    * Helminths
    * Testing for Parasitic Diseases

    Viruses
    * Herpes viruses
    * Rubella (German Measles)
    * Rubeola (Measles)
    * Retroviruses
    * Respiratory Viruses
    * Enteroviruses
    * Polio
    * Rotavirus
    * Calcivirus
    * Hepatitis Viruses
    * Rabies
    * Mumps
    * Parvovirus B19
    * Arboviruses
    * Chikungunya Virus
    * Dengue Fever
    * Zika Virus
    * Hantavirus
    * Ebola Virus
    * Slow Viruses
    * Prion Diseases

    HIV and AIDS
    * Note
    * Virus Structure and Life Cycle
    * Prevalence and Transmission
    * Signs and Symptoms
    * Diagnosis
    * Treatment of HIV Infection

    Antibiotics
    * Overview
    * Inhibitors of Cell Wall Synthesis and Function
    * Inhibitors of Protein Synthesis
    * Inhibitors of DNA Synthesis and Function
    * Antibiotics and the Pregnant or Breastfeeding Woman

    Antibiotic Overuse

    Antiviral Agents

    Antifungal Agents
    * Polyenes
    * Imidazoles
    * Triazoles
    * Echinocandins
    * Other Systemic Antifungals
    * Other Topical Antifungals

    Antiparasitic Drugs

    Dermatology

    Neonatal Dermatology
    * Aplasia Cutis Congenita
    * Rashes
    * A Few Infectious Rashes
    * Vascular Abnormalities
    * Pigmented Lesions

    Genetic Skin Disorders
    * Ichthyoses
    * Genetic Pigmentation Disorders
    * Neurocutaneous Disorders
    * Epidermolysis Bullosa (EB)
    * Ehlers
    * Danlos Syndrome
    * Genetic Disorders of the Hair, Nails, Sweat Glands, Sebaceous Glands, and Teeth

    Disorders of Pigmentation
    * Nevi
    * Vitiligo
    * Lichen Striatus
    * Lichen Nitidus
    * Lichen Sclerosus
    * Acanthosis Nigricans
    * Hyperpigmentation
    * Mastocytosis

    Common Skin Problems
    * Atopic Dermatitis
    * Seborrheic Dermatitis
    * Intertrigo
    * Contact Dermatitis
    * Infantile Acne
    * Acne Vulgaris
    * Acne Rosacea
    * Alopecia
    * Hidradenitis Suppurativa
    * Terra Firma
    * Forme Dermatosis (TFFD)
    * Keratolysis Exfoliativa

    Oral Findings

    Cutaneous Drug Reactions
    * Overview
    * Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)

    Inflammatory Skin Diseases
    * Psoriasis
    * Reactive Arthritis
    * Cutaneous Lupus
    * Neonatal Lupus
    * Sarcoidosis
    * Erythema Nodosum (EN)
    * Pyoderma Gangrenosum (PG)
    * Juvenile Dermatomyositis (JDM)
    * Vasculitis
    * Pityriasis Lichenoides Et Varioliformis Acuta (PLEVA)

    Vitamin Deficiencies
    * Hyperpigmentation
    * Zinc Deficiency
    * Eruption Seen in Cystic Fibrosis
    * Biotin Deficiency
    * Essential Fatty Acid Deficiency

    Skin Infections
    * Bacterial Infections
    * Rickettsial Infections
    * Spirochetal Infections
    * Viral Infections
    * Fungal Infections
    * Parasitic Infections

    Purpura
    * Overview
    * Hemostasis Abnormalities
    * Defects in Vascular Integrity

    Blistering Lesions
    * Pemphigus Vulgaris
    * Porphyria Cutanea Tarda (PCT)
    * Photosensitivity Reactions
    * Dermatitis Herpetiformis (DH)
    * Papular Urticaria
    * Erythema Multiforme (EM)
    * Linear IgA Bullous Dermatosis

    Round and Annular Lesions
    * Granuloma Annulare (GA)
    * Nummular Eczema
    * Pityriasis Rosea

    Biostatistics, Ethics, Patient Safety, and Quality Improvement

    Biostatistics
    * Diagnostic Testing and Screening
    * Study Designs and Data Analysis

    Evidence-Based Medicine
    * Formulating a Clinical Question
    * Searching for Evidenc
    * Critical Appraisal of the Literature
    * Applying the Evidence

    Ethics
    * Autonomy, Beneficence, and Rights
    * Special Medical Circumstances

    Quality and Safety
    * Clinical Quality Measurements
    * Prevention Strategies to Reduce Medical Errors
    * Patient Experience

    Rheumatology

    Juvenile Idiopathic Arthritis (JIA)
    * Terminology / Occurrence
    * JIA Types
    * Differential Diagnosis
    * Treatment
    * Outcomes

    Arthritis Associated with Inflammatory Bowel Disease (IBD)

    Infection-Related Arthritis
    * Infectious Arthritis
    * Reactive Arthritis

    Vasculitides
    * Overview
    * Small-Vessel Vasculitides
    * Medium-Vessel Vasculitides
    * Large-Vessel Vasculitis
    * Vasculitides of > 1 Vessel Size

    Multisystem Inflammatory Syndrome in Children (MIS-C)

    Systemic Lupus Erythematosus (SLE)
    * Overview
    * Diagnosis
    * Treatment
    * Prognosis

    Mixed Connective Tissue Disease (MCTD)

    Sjörgren Syndrome (SS)

    Autoimmune Myopathies
    * Overview
    * Juvenile Dermatomyositis (JDM)
    * Juvenile Polymyositis

    Scleroderma
    * Scleroderma Disorders
    * Localized Scleroderma
    * Juvenile Systemic Sclerosis (JSSc)

    Sarcoidosis

    Pain Syndromes
    * Growing Pains
    * Hypermobility Syndrome
    * Amplified Musculoskeletal Pain Syndromes (AMPS)

    Amyliodosis

    Periodic Fever Syndromes
    * Overview
    * Periodic Fever, Aphthous Stomatitis, Pharyngitis and Cervical Adenitis (PFAPA) Syndrome
    * Familial Mediterranean Fever (FMF)
    * Hyper–Immunoglobulin D Syndrome (HIDS)
    * Cryopyrin-Associated Periodic Syndromes (CAPS)
    * Other Causes of Periodic Fevers

    Ophthalmology & ENT

    Normal Visual Development
    * Anatomy of the Eye
    * Some Important Basics

    Eye Disorders
    * Overview
    * Cataracts
    * Retinopathy of Prematurity (ROP)
    * Dacryostenosis (Nasolacrimal Duct Obstruction)
    * Stye / Chalazion
    * Strabismus
    * Amblyopia
    * Color Vision Defects
    * Cortical Visual Impairment
    * Nystagmus
    * Optic Nerve Hypoplasia
    * Glaucoma
    * Painful Erythematous Eye
    * Preseptal and Orbital Cellulitis
    * Papilledema
    * Retinoblastoma
    * Subconjunctival Hemorrhage
    * Hyphema
    * Orbital Blowout Fracture

    Ear Disorders
    * Anatomy of the Ear
    * Preauricular Sinuses and Pits
    * External Ear
    * Middle Ear
    * Hearing Problems
    * Tympanograms

    Congenital Disorders of the Nose
    * Choanal Atresia

    Acquired Disorders of the Nose
    * Nasal Foreign Body
    * Epistaxi
    * Nasal Polyps
    * Nasal Fractures
    * Nasal Septal Hematoma

    Congenital Disorders of the Mouth and Pharynx
    * Cleft Lip and Palate
    * Lingual Ankyloglossia (Tongue-Tie)
    * Lingual Thyroid
    * Thyroglossal Duct Cysts

    Teeth

    Infections of the Mouth, Nose, Pharynx, and Upper Respiratory Tract
    * The Common Cold
    * Acute Sinusitis
    * Chronic Rhinosinusitis
    * Submandibular Space Infection (Ludwig Angina)
    * Acute Pharyngitis
    * Peritonsillar Abscess (PTA)
    * Retropharyngeal Abscess
    * Tonsillectomy
    * Adenoidectomy

    Neck
    * Cervical Lymphadenopathy (LA)
    * Laryngitis / Hoarseness
    * Neck Mass

    Obstructive Sleep Apnea (OSA)

    Genetics

    Key Definitions in Genetic Disorders

    Risks of Genetic Disease and Diagnostic Testing
    * Genetic Disease Risk Factors
    * Prenatal Testing
    * Postnatal Diagnostic Testing

    Chromosomal Defects
    * Overview
    * Autosomal Trisomy Syndromes
    * Sex Chromosome Syndromes
    * Microdeletion Syndromes
    * Duplication

    Single Gene Defects
    * Patterns of Inheritance

    Multifactorial Inheritance

    Twins Facts

    Genetic Conditions Organized by Presenting Symptoms
    * Poor Growth / Short Stature
    * Bone Marrow Dysfunction
    * Chromosomal Instability Syndromes
    * Craniofacial Malformations
    * Skeletal Dysplasias
    * Bone Fragility Disorders — Osteogenesis Imperfecta (OI)
    * Connective Tissue Disorders
    * Neurocutaneous Syndromes
    * Familial Cancer Syndromes
    * Congenital Anomaly Syndromes

    The MedStudy Hub: Your Guidelines and Review Articles Resource

    Appendix — Congenital Anomaly Syndromes

    Metabolic Disorders

    Inborn Errors of Metabolism (IEMs)
    * Metabolism Review
    * Causes
    * Inheritance Patterns
    * Mitochondrial Inheritance

    Intoxications
    * Overview
    * Presentations
    * Disorders of Amino Acid Metabolism
    * Urea Cycle Disorders
    * Organic Acidemias
    * Sugar Intolerances

    Energy Utilization Defects
    * Overview
    * Presentation
    * Defects in Fat Metabolism
    * Glycogen Storage Diseases (GSDs)
    * Mitochondrial DNA (mtDNA) Disorders

    Complex-Molecule Defects
    * Overview
    * Lysosomal Storage Disorders
    * Sphingolipidoses
    * Peroxisomal Disorders
    * Disorders of Mineral Absorption or Metabolism
    * Purine Disorders
    * Disorders of Lipids and Lipoproteins

    Newborn Screening (NBS)

    Hematology

    Developmental Changes of Red Blood Cells (RBCs)
    * Sites of Blood Formation
    * RBC Indices
    * Production Rates and Normal Values
    * Hemoglobin
    * Oxygen Transport

    Anemia
    * Normal Erythropoiesi
    * Clinical Manifestations
    * Laboratory Results
    * Etiology

    Stem Cell Disorders
    * Aplastic Anemia
    * Fanconi Anemia
    * Red Cell Aplasia

    White Blood Cell (WBC) Disorders
    * Neutropenia
    * Disorders of Neutrophil Function
    * Disorders of Eosinophils
    * Disorders of Basophils

    Hemostasis
    * Hemostatic Process
    * Normal Clotting Sequence
    * Clot Limitation and Dissolution
    * Clinical Evaluation of Bleeding Disorders
    * Lab Tests in Bleeding Disorders
    * Disorders of Primary Hemostasis
    * Disorders of Secondary Hemostasis
    * Thrombotic Disorders
    * Anticoagulation Treatment
    * Transfusion Treatment

    Oncology

    Cancer Incidence

    Hematologic Malignancies
    * Leukemia
    * Lymphoma

    Tumors of the Central Nervous System (CNS)
    * Overview
    * Epidemiology of Brain Tumors
    * Presentation
    * Diagnosis
    * Treament
    * Glioma
    * Medulloblastomas
    * Ependymoma
    * Germ Cell Tumors (GCTs)
    * Craniopharyngioma
    * Meningioma
    * Spinal Cord Compression from a Mass

    Neuroblastoma
    * Occurrence
    * Pathology
    * Presentation
    * Diagnosis
    * Treatment
    * Prognostic Indicators

    Wilms Tumor
    * Overview
    * Pathology and Staging
    * Presentation
    * Treatment

    Rhabdomyosarcoma
    * Occurrence
    * Pathology
    * Presentation
    * Diagnosis
    * Treatment

    Retinoblastoma
    * Occurance
    * Pathology
    * Presentation
    * Diagnosis
    * Treatment

    Bone Neoplasms and Benign Tumors
    * Overview
    * Osteosarcoma

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