7th Edition Pediatrics Review Core Curriculum

The Fetus & Newborn: Page 1-1, Mortality / Morbidity in Newborns > Common Terms

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Preterm: an infant born before the last day of the 37th week (259th day) of gestation (i.e., born before the 38th week of gestation).

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Preterm: an infant born before the 37th week (259th day) of gestation.

Gastroenterology & Nutrition: Page 14-1, Nutritional Disorders > Fat-Soluble Vitamin

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Typically, vitamin A deficiency results in night blindness, Bitot spots (keratinization of the cornea),

xerophthalmia (dry eyes), corneal opacities, growth failure, increased susceptibility to infection, and even death.

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Typically, vitamin A deficiency results in night blindness, Bitot spots (keratinization of the conjunctiva),

xerophthalmia (dry eyes), corneal opacities, growth failure, increased susceptibility to infection, and even death.

Hematology: Page 16-20, Differentiating the Pure Red Cell Aplasias

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A child comes in with anemia without low reticulocytes, especially consider the aforementioned disorders: parvovirus B19, TEC, and congenital hypoplastic anemia (Diamond-Blackfan anemia).

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A child comes in with anemia with low reticulocytes, especially consider the aforementioned disorders: parvovirus B19, TEC, and congenital hypoplastic anemia (Diamond-Blackfan anemia).

Cardiology: Page 12-26, Complete (d-) Transposition of the Great Arteries

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Because the great arteries are completely transposed, the aorta is connected to the right ventricle instead of the left ventricle, and the pulmonary artery is connected to the left atrium instead of the right atrium.

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Because the great arteries are completely transposed, the aorta is connected to the right ventricle instead of the left ventricle, and the pulmonary artery is connected to the left ventricle instead of the right ventricle.

Allergy & Immunology: Page 6-12, Phagocyte Disorders > Overview

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  1. Neutropenia (< 1,000 PMN, severe = < 100):
    • Kostmann syndrome (AD)
    • Severe chronic neutropenia (AR)

Text should read:

  1. Neutropenia (< 1,000 PMN, severe = < 100):
    • Kostmann syndrome (AR)
    • Severe chronic neutropenia (AD)

Growth & Development: Page 1-1, Overview of Growth

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Remember that 5% of the population have heights, weights, or head circumferences that normally lie outside of 2 standard deviations from the mean. (By definition, 2.5% are > 95th percentile, and 2.5% are < 5th percentile.)

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Remember that 5% of the population have heights, weights, or head circumferences that normally lie outside of 2 standard deviations (SDs) from the mean. (By definition, 2.5% are > +2 SD and 2.5% are < –2 SD).

Cardiology: Page 12-26, Complete (d-) Transposition of the Great Arteries

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Because the great arteries….and the pulmonary artery is connected to the left atrium instead of the right atrium.

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Because the great arteries….and the pulmonary artery is connected to the left ventricle instead of the right ventricle.

Infectious Disease: Page 5-2, Gram-Positive Bacteria/Staphylococcus aureus

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Mild: Patients with a fever, who are immunocompetent can sometimes be managed similarly to those with mild cases. Or, patients with moderate infections may require hospitalization if the area of involvement is extensive, if they have significant systemic symptoms, or if medication adherence is an issue.

Note: The D-test determines if there is macrolide-inducible clindamycin resistance. The test must be done when the S. aureus isolate is erythromycin-resistant but shows clindamycin susceptibility. If the D-test is positive, do not use clindamycin as treatment. Most microbiology laboratories perform this test routinely and report only clindamycin susceptibility based on its result.

Moderate: Previously healthy patients who have fever can be managed similarly to the mild cases. Or, they may require hospitalization and managed similar to severe cases if the area of involvement is extensive; if they have significant systemic symptoms; or if medication adherence is an issue.

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Mild: Afebrile patients who are immunocompetent can sometimes be managed with incision and drainage alone. Often they require oral antibiotic therapy which includes trimethoprim/sulfamethoxazole, clindamycin, or doxycycline (if > 7 years old).

Note: The D-test determines if there is macrolide-inducible clindamycin resistance. The test must be done when the S. aureus isolate is erythromycin-resistant but shows clindamycin susceptibility. If the D-test is positive, do not use clindamycin as treatment. Most microbiology laboratories perform this test routinely and report only clindamycin susceptibility based on its result.

Moderate: Previously healthy patients who have fever can be managed similarly to the mild cases. Or, they may require hospitalization and managed similar to severe cases if the area of involvement is extensive; if they have significant systemic symptoms; or if medication adherence is an issue.

Growth & Development / Preventive Pediatrics: Page 1-19, Cholesterol and Lipid Screening

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Consider pharmacologic therapy at 10 years of age in children with an LDL-C ≥ 190 mg/dL…

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Consider pharmacologic therapy at 8 years of age in children with an LDL-C ≥ 190 mg/dL…

Adolescent Health and Gynecology: Page 4-27, Pelvic Inflammatory Disease

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Recommended treatment:

  • Cefoxitin 2 gm IV every 6 hours, plus

Doxycycline 100 mg orally or IV every 12 hours for 14 days

Outpatient treatments for PID:

  • Other 3rd generation cephalosporins, plus
    Doxycycline 100 mg 2x/day for 14 days +/

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Recommended treatment:

  • Cefoxitin 2 gm IV every 6 hours, plus

Doxycycline 100 mg 2x/day PO x 14 days

Outpatient treatments for PID:

  • Other 3rd generation cephalosporins, plus
    Doxycycline 100 mg 2x/day PO x 14 days +/

Metabolic Disorders: Page 10-6, Phenylalanine-Tyrosine Disorders, Tyrosinemia,
Hereditary Tyrosinemia Type I

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You can treat liver failure and Fanconi syndrome of hepatorenal tyrosinemia with 2-(nitro-4-trifuoro-methylbenzoyl)-1,3-cyclohexanedione…

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You can treat liver failure and Fanconi syndrome of hepatorenal tyrosinemia with 2-(2-nitro-4-trifluoro-methylbenzoyl)-1,3-cyclohexanedione… 

Metabolic Disorders: Page 10-7, Sulfur-Containing Amino Acid Defects, Homocystinuria

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Classically, the term was used specifically to indicate disease due to a defect in the cystathionineβ-synthetase enzyme.

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Classically, the term was used specifically to indicate disease due to a defect in the cystathionine β-synthase enzyme.